Q: A lady asks what she can do, if anything, about the fact that she has lost quite a lot of muscle at the top of her thighs and suffers pain, also in the bones on the front of her legs. A scan a year ago was fine.

A: Your member should not lose muscle at the top of her legs because of Addison's Disease or it's replacement. Muscle mass is only lost at the top of the legs due to replacement therapy if this is excessive. It is to prevent the exposure to such excessive levels that we carry out regular day curve measurements of hydrocortisone levels in the blood on the patient's ordinary replacement. If your member is having correct replacement therapy then such muscle loss, like the pain in the bones at the front of the legs, must be due to something else.